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Tramadol is a synthetic opioid analgesic that provides long-lasting analgesic effects. This drug directly affects the central nervous system and spinal cord, blocking the conduct of pain impulses and enhancing the impact of other sedatives. Tramadol, which activates opioid receptors of the brain and gastrointestinal tract, prevents the destruction of catecholamine and supports their concentration in the central nervous system, as well as initiates the opening of calcium and potassium channels. To buy Tramadol online is very easy, but first read more about it.

In remedial applications, Tramadol does not cause a pronounced effect on hemodynamic and the respiratory system does not cause changes in the pressure in the pulmonary artery, but is able to slightly slow down intestinal peristalsis. In addition to the analgesic effect, the drug has a light sedative (soothing) and antitussive effect.

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Tramadol is quickly absorbed from the gastrointestinal tract, its bioavailability reaches 68% and 100% when administered intramuscularly. The active substance is Tramadol hydrochloride, easily penetrates the placenta, the blood-brain barrier, and is eliminated in breast milk. The drug is metabolized in the liver, excreted from the body by the kidneys.

The therapeutic effect occurs within 15 to 30 minutes after taking the pill and lasts for 6 to 8 hours. The danger of this drug is that if Tramadol is taken for a long time, it can provoke the development of drug addiction.

Indications

Tramadol is created for the relief of moderate to strong pain. Such painful sensations can appear in the postoperative and post-traumatic period, or manifest in vascular, inflammatory disorders or oncological diseases.

In addition, the doctor may prescribe Tramadol before performing a diagnostic or therapeutic procedure that is accompanied by severe pain.

The main guidelines for the treatment with Tramadol


  • Tell your physician if you have an allergy to Tramadol components or other substances, as this medication contains some components substances that may be dangerous for your health.
  • Inform your doctor if you have suffered from kidney/liver dysfunction, mood swings or mental disorders like depression/suicidal tendencies, alcoholism or substance abuse, lung disease or any muscle pathology, such as myasthenia gravis.
  • It is important to get a proper sleep (8 hours or more), as otherwise the effect of the medication can last even when you wake up.
  • Avoid any heavy works, driving or doing anything that requires high concentration, Tramadol can cause sleepiness.
  • During the treatment you should refrain from alcohol. Tell your physician if you’re going to have any operation or dental surgery that you have Tramadol or any other prescription or non-prescription drugs.
  • Consult your physician before starting the treatment with Tramadol during pregnancy or lactating to limit any undesirable adverse effects.

Your doctor will define the suitable dosage of Tramadol, which depends on your age, health state and reaction to the drugs, as well as some other comparable factors. The initial dose of Tramadol is 50 mg a day (preferably in the morning). Your doctor may change your dosage every now and then according to your body’s reaction to the drug. The maximum daily dosage is 300-400 mg of the drug.

To treat strong pain that accompanies cancer or conditions in the postoperative period, the doctor may raise the dose of the medicine. In elderly and debilitated patients with chronic diseases, the exclusion of the drug may be slowed down. Therefore, the time interval between Tramadol injections can be increased.

Adverse reaction

Tramadol is a serious drug, it should be used only for indications, since its toxic effect on the body can lead to the development of the following conditions:

  • On the part of the heart and blood vessels, there is often a phenomenon such as a decrease in pressure (orthostatic hypotension), which can provoke fainting, tachycardia, collapse.
  • The CNS reacts to taking the drug with dizziness, headache, increased nervousness or, on the contrary, inhibition. Patients complain of weakness, increased sweating, sleep violations, daytime drowsiness, emotional instability, and anxiety. Sometimes it is possible to develop depressive states, confusion, manifestations of amnesia, instability of gait. In severe cases it was observed the occurrence of hallucinations, seizures, suicidal attempts.
  • The digestive system reacts with intestinal disorders (constipation or diarrhea), nausea, abdominal pain, flatulence, dry mouth.
  • Disorders of the urinary system are expressed in difficult urination, urinary retention, dysuria.
  • Often there are allergic reactions that are manifested by itching, bullous rash or urticaria. In addition, a narcotic analgesic can cause a change in taste sensations, a failure of the menstrual cycle in women, and visual impairment.
  • The main danger of opiate analgesics is the danger of addiction. Abrupt discontinuation of the drug causes withdrawal syndrome. This condition is followed by a strong craving for analgesics, the appearance of muscle cramps, runny nose, sneezing, lacrimation. There are digestive disorders, nausea, fever, insomnia, tachycardia, increased blood pressure. To avoid unpleasant consequences, buy Tramadol online and take it for a short time. It should be canceled gradually.

An overdose of Tramadol can lead to such dangerous conditions as indomitable vomiting, seizures, respiratory suppression, respiratory obstruction, collapse, coma. In these cases, urgent medical care and therapeutic measures aimed at maintaining the functions of the respiratory and cardiovascular systems are necessary. After the condition improves, symptomatic treatment is performed.

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